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Rita Marchi Cappelletti
Rita Marchi Cappelletti
Developmental Biology Section of Hemostasis, Bolivarian Republic of Venezuela,
Caracas 1020A, PO Box 20632
Venezuela
Publications
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Research Article
Statins Therapy: Effects on Plasma Fibrinogen Levels and Fibrinolysis
Author(s): Rita Marchi CappellettiRita Marchi Cappelletti
Elevated plasma fibrinogen levels have been identified as an independent and strong risk factor for cardiovascular disease. At present, there are no selective oral agents that lower fibrinogen; however different drugs can influence its levels as ticlopidine (inhibitor of platelet aggregation) and fibrates (lipid lowering drugs). Statins lower cholesterol by inhibiting HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase, which catalyzes the conversion of HMGCoA to mevalonate, the rate limiting step in cholesterol biosynthesis. In addition to lowering cholesterol, several non-lipids related benefits of statins have been reported. Briefly, statins improve endothelial function, modulate the inflammatory response, may stabilize atherosclerotic plaques, restrain thrombus formation, and others. Many of these are mediated by their ability to block the .. View More»
DOI: 10.4172/2161-0509.S6-001