Journal of Tropical Diseases & Public Health

Richard Besingi

Publications

• Research Article
  Plasma Levels of Tumour Necrosis Factor-Alpha, Interleukin-10, Interleukin-12, Macrophage Inhibition Factor and Transforming Growth Factor-Beta in Children with Severe and Uncomplicated Falciparum Malaria
  Author(s): Eric Akum Achidi, Tobias O Apinjoh, Clarisse N Yafi, Richard Besingi, Judith K Anchang, Nancy W Awah and Marita Troye-BlombergEric Akum Achidi, Tobias O Apinjoh, Clarisse N Yafi, Richard Besingi, Judith K Anchang, Nancy W Awah and Marita Troye-Blomberg
  
  The outcome of an infection appears to hinge on a delicate balance between appropriate and inappropriate induction of inflammatory/anti-inflammatory cytokines. However, the role of these mediators in the pathogenesis of severe malaria remains controversial. In this study, plasma levels and ratios of the pro- (TNF-α, IL-12 and MIF), and the anti-inflammatory (IL-10 and TGF-β) cytokines were determined and compared in patients with cerebral malaria (CM), severe malaria anaemia (SMA), uncomplicated malaria (UM), and healthy control (HC) children below 14 years of age. TNF-α, IL-10 and TGF-β levels were significantly different among the four clinical groups, while IL-12 and MIF levels were similar among the clinical groups. TNF-α level were higher in SMA and UM, when compared with HC. Additionally, TNF-α levels were higher (P=0.002) in the combined se.. View More»
  DOI: 10.4172/2329-891X.1000103

  Abstract PDF