Rema Razdan
India
Research Article
Thyroxine: A Putative Neuroprotectant in Diabetes Induced Peripheral Neuropathy in Rats
Author(s): Hariprasad MG, Rema Razdan, Yasha TC and Tripathy Amrutanand SHariprasad MG, Rema Razdan, Yasha TC and Tripathy Amrutanand S
Objectives: The treatment options for diabetic peripheral neuropathy (DPN) currently include anti-depressants, anti-convulsants and opioid analgesics. These agents are modestly effective for symptomatic relief, but they do not affect the underlying pathology nor do they slow progression of the disease. Therefore, effective treatment for diabetes induced neuropathy would be a major advantage for patients. It is well established. TH plays an important role in regulating the development and regeneration of the nervous system and local administration of triiodothyronine (T3) at the level of transected rat sciatic nerve increased the number and diameter of regenerated axons and SCG10 protein levels about two-fold in the different segments of transected nerve during the regeneration period. Thyroxine(T4) has shown the range of biological actions and is important in both development and matu.. View More»
