Journal of Blood Disorders & Transfusion

Ream Elzain Abdelgadir

Publications

• Research Article
  Interleukin-4 Intron 3 VNTR Polymorphism Gene in Leukemic Patients
  Author(s): Abeer Ahmed, Ream Elzain Abdelgadir, Abdel Rahim Mahmoud Muddathir, Elshibli Mohamed Elshibli and Imad Fadl ElmulaAbeer Ahmed, Ream Elzain Abdelgadir, Abdel Rahim Mahmoud Muddathir, Elshibli Mohamed Elshibli and Imad Fadl Elmula
  
  Background: Leukemia is a group of chronic malignant disorders of White blood cells and its precursor. Interleukin-4 (IL-4) is inflammatory cytokine that determines the activation and differentiation of B-cells, mast cells, erythroid progenitors. Several studies have investigated the association between IL-4 intron 3 variable number of tandem repeats (VNTR) polymorphism and cancer risk in humans; however, this association is not investigated among patients with leukemia. Material and Methods: The present study aimed to investigate genotype and allele frequencies of IL-4 gene intron 3(VNTR) polymorphism in patients with leukemia compared to healthy control. The study included 231 patients with leukemia and 163 healthy controls. Genomic DNA was isolated from 3 ml of anticoagulated venous blood samples by modified salting out method. IL-4 intro.. View More»
  DOI: 10.4172/2155-9864.1000357

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