Journal of Clinical & Experimental Pharmacology

Ram Rup Sarkar

Publications

• Research Article
  Drug Targets and Biomarker Identification from Computational Study of Human Notch Signaling Pathway
  Author(s): Saikat Chowdhury and Ram Rup SarkarSaikat Chowdhury and Ram Rup Sarkar
  
  Notch signaling pathway is widely implicated in controlling various cellular functions, cell fate determination, and stem cell renewal in human but aberrant activity in cancer stem cells may cause different types of cancers. Understanding the complexity of this pathway to identify important targets for cancer therapy and to suppress the pathway activity without affecting the normal functions is of utmost importance to clinical and experimental pharmacologists. For developing therapeutic strategy, non availability of detailed molecular interactions, complex regulations and cross talks with other pathways pose a serious challenge to get a coherent understanding of this pathway. This motivated us to reconstruct the largest human cell specific Notch pathway with more number of molecules and interactions available from literatures and databases. To identify probable drug targets and biomar.. View More»
  DOI: 10.4172/2161-1459.1000137

  Abstract PDF