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Raghavan PR
Raghavan PR
Nanorx Inc,
PO Box 131, Chappaqua, NY, 10514
Tanzania
Publications
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Research Article
Metadichol® a Novel Sialidase Inhibitor
Author(s): Raghavan PR, Yogisha S, Anand S and Purushotham GVRaghavan PR, Yogisha S, Anand S and Purushotham GV
Humans face a constant threat from pathogens like influenza varieties H1N1, H5N1, and others and there is a need to prevent these from epidemics. The pathogens depend on successful colonization of the host in order to reproduce and multiply. Sialidases are known as neuraminidases are a group of enzymes, the most abundant of these being the exo-sialidases that can catalyze the cleavage of sialic acids from carbohydrates, glycoproteins or glycolipids. Sialidases have been thoroughly studied since their discovery 75 years ago and their occurrence in bacteria and viruses is widespread. They are found in diverse virus families and bacteria and other microbes. Moreover, sialic acids serve as a receptor for various pathogens. This allows bacteria like H1N1 or other influenza viruses, to enter the host cell. There is a need to block sialidases as they release sialic acid that serves as nutrit.. View More»