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R. N. Saha
R. N. Saha
India
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Research Article
Comparative Bioavailability of Two Brands of Ofloxacin in Healthy Human Volunteers
Author(s): Rajani Shakya, Manila Hada, Panna Thapa and R. N. SahaRajani Shakya, Manila Hada, Panna Thapa and R. N. Saha
The relative bioavailability and pharmacokinetics of a locally manufactured (Oquin) and reference (Zanocin) formulations of ofloxacin were compared . Each volunteer received a single dose of 200 mg ofloxacin tablet , test or reference with a 7 days washout period. Multiple blood samples were collected and plasma concentrations of ofloxacin were analyzed by high performance liquid chromatography technique. Following oral administration of both formulations, there was rapid and extensive oral absorption from gastrointestinal tract achieving maximum serum concentration within 2 hrs. The concentration-time pro fi l e g e n e r a t e d b y t h e t w o p r o d u c t s was found to be superimposable. Peak plasma concentration (C m a x ), area under the serum concentration-time curve (AUC 0 - 2 4 ), area under the serum concentration-time curve extrapolated to in fi n i t y ( A U C 0 - ∞.. View More»
DOI: 10.4172/jbb.1000031