Journal of Clinical & Experimental Pharmacology

Pradeep Kumar M

Publications

• Research Article
  An Investigation of Hepatoprotective Activity of Methanolic Extract of Ipomoea reniformis on Experimentally Induced Ethanol Hepatotoxicity in Rats
  Author(s): Neelima S, Pradeep Kumar M and Hari Kumar CNeelima S, Pradeep Kumar M and Hari Kumar C
  
  Objective: The present study evaluated the hepatoprotective activity of Methanolic Extract of Ipomoea reniformis (MEIR) in experimentally-induced hepatotoxic rats. Methods: Hepatoprotective activity of MEIR was studied against ethanol (4 g/kg p.o.)-induced hepatotoxicity rats. Silymarin (100 mg/kg p.o.) was used as a standard reference. The following parameters were evaluated; serum biomarkers such as Serum Glutamate Oxaloacetic Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), total and direct bilirubin, Total Protein (TP) and tissue antioxidant levels such as Glutathione (GSH) and Lipid Peroxidation (LPO). Results and conclusion: The control group did not exhibit increase in serum parameters, but ethanol toxicant group showed significant increase in serum parameters such as SGOT, SGPT, bilirubin (total and direct), and LPO, whereas GSH and TP levels were markedly reduc.. View More»
  DOI: 10.4172/2161-1459.1000227

  Abstract PDF