Pradeep Krishna Shrestha
Nepal
Research Article
Determination of Insulin Resistance and Beta-Cell Function Using Homeostatic Model Assessment in Type 2 Diabetic Patients at Diagnosis
Author(s): Prashant Basukala, Bharat Jha, Binod K. Yadav and Pradeep Krishna ShresthaPrashant Basukala, Bharat Jha, Binod K. Yadav and Pradeep Krishna Shrestha
Objective: Despite the increasing incidence of type 2 diabetes mellitus (T2DM) in South Asian countries, there have been no studies related to insulin resistance (IR) and beta-cell function (BCF) in Nepal. Measurement of both of these parameters at T2DM diagnosis can be a potential tool in evaluation, risk stratification and monitoring treatment. In this study, we used C-peptide modified homeostatic model assessment (both HOMA1 and HOMA2) and correlated the obtained IR with cardiovascular risk factors. We also intended to find out whether reduced insulin sensitivity or beta-cell failure predominates in new T2DM cases. Also there has been some dilemma in using either body mass index (BMI) or waist-hip ratio (WHR) as a better predictor of IR in our population. Lipoprotein ratios TC/ HDL and TG/HDL also needed evaluation in this regard.Results: Par.. View More»
