Ping Ma

Ping Ma

Tanzania

Publications
  • Research Article
    Paclitaxel Nano-Delivery Systems: A Comprehensive Review
    Author(s): Ping Ma and Russell J. MumperPing Ma and Russell J. Mumper

    Paclitaxel is one of the most effective chemotherapeutic drugs ever developed and is active against a broad range of cancers, such as lung, ovarian, and breast cancers. Due to its low water solubility, paclitaxel is formulated in a mixture of Cremophor EL and dehydrated ethanol (50:50, v/v) a combination known as Taxol. However, Taxol has some severe side effects related to Cremophor EL and ethanol. Therefore, there is an urgent need for the development of alternative Taxol formulations. The encapsulation of paclitaxel in biodegradable and non-toxic nanodelivery systems can protect the drug from degradation during circulation and in-turn protect the body from toxic side effects of the drug thereby lowering its toxicity, increasing its circulation half-life, exhibiting improved pharmacokinetic profiles, and demonstrating better patient compliance. Also, nanoparticle-based delivery syst.. View More»
    DOI: 10.4172/2157-7439.1000164

    Abstract PDF