Journal of Neonatal Biology

Phillip J DeChristopher

Publications

• Research Article
  Immunohistochemical Demonstration of Blood Group Antigen Expression in Intestinal Endothelium Links Blood Type and Necrotizing Enterocolitis
  Author(s): Charissa L Manuat, Sherri J Yong, Phillip J DeChristopher, Christina A Kwong, Loretto A Glynn, Omar Habeeb, Tricia L Thomson and Jonathan K MuraskasCharissa L Manuat, Sherri J Yong, Phillip J DeChristopher, Christina A Kwong, Loretto A Glynn, Omar Habeeb, Tricia L Thomson and Jonathan K Muraskas
  
  Objectives: To determine the presence of A and B blood group antigens on vascular endothelial cells of intestinal tissue and compare tissue resected for necrotizing enterocolitis (NEC) with tissues resected for non-NEC pathologies (spontaneous intestinal perforation (SIP), intussusception, Hirschsprung disease, intestinal atresia, etc.) in an effort to implicate blood group antigen expression on bowel endothelium as a mechanism of bowel injury in NEC via a humoral immune-mediated inflammatory response. Methods :Intestinal tissue from 21 patients with NEC and 23 non-NEC patients (5 of which were SIP) was stained with monoclonal antibodies against blood group antigens A and B. Vascular endothelial lined spaces were examined for expression of these blood group antigens and graded as 0 (no staining) to 3 (marked staining). Results: .. View More»
  DOI: 10.4172/2167-0897.1000211

  Abstract PDF