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Peng-Fei YUE
Peng-Fei YUE
China
Publications
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Research Article
Preparation, Characterization and Pharmacokinetics in Vivo of Oxymatrine-Phospholipid Complex
Author(s): Peng-Fei YUE, Hai-Long YUAN, Ming Yang and Wei-Feng ZHUPeng-Fei YUE, Hai-Long YUAN, Ming Yang and Wei-Feng ZHU
The aim of the present study was to prepare oxymatr ine– phospholipid complex to enhance oral bioavailabilit y of oxymatrine and to study its physicochemical propert ies and to compare the pharmacokinetic characteristics and bioavailability after oral administration of oxymat rine– phospholipid complex in rats. Using tetrahydrofuran as a reaction medium, oxymatrine and phospholipids were re- solved into the medium, after the organic solvent w as re- moved under vacuum condition, oxymatrine–phospholip id complex was formed. The new complex’s physicochemi- cal properties including differential scanning calo rimetry (DSC), X-ray diffraction (XRD), N-octanol/water Par ti- tion Coefficient were tested. The concentrations of oxymatrine after oral administration of oxymatrine– phos- pholipids complex and oxymatrine at different time in rats were determined by HP.. View More»
DOI: 10.4172/jbb.1000015