Journal of Clinical & Experimental Pharmacology

Onyango TO

Publications

• Research Article
  Effects of Maalox Plus^® Antacid and PureCal^® Calcium Supplement on Physical Characteristics, Body Weight, Tissue Minerals and Histopathology of Rats Subjected to Alcohol Intoxication
  Author(s): Onyango TO, Mburu DN, Ngugi MP, Kamau JK and Juma KKOnyango TO, Mburu DN, Ngugi MP, Kamau JK and Juma KK
  
  Overconsumption of alcohol is associated with morbidity including depletion of the body’s stores of magnesium and calcium. Conversely therapy with magnesium (Mg) and calcium (Ca) in the event of chronic alcoholism normalizes elevated enzyme activities. Similar information on acute alcohol intoxication is missing. This study examined the effects of Maalox plus® antacid and pureCal® calcium supplement which are rich in Mg and Ca, respectively, on the body weight, tissue magnesium and calcium together with histopathology of rats exposed to acute alcohol intoxication. Alcohol was administered orally at a dosage 5 g/kg body weight for five days and supplements for two days of the week for duration of 28 days. The animals were weighed weekly and tissues obtained at the end of the treatment regimen. Statistical comparison was done using one way ANOVA followed by Tukey’s t.. View More»
  DOI: 10.4172/2161-1459.1000237

  Abstract PDF