Journal of Clinical & Experimental Pharmacology

Oleksandr Gryshkov

Publications

• Research Article
  Coaxial Electrospinning as a Process to Engineer Biodegradable Polymeric Scaffolds as Drug Delivery Systems for Anti-Inflammatory and Anti- Thrombotic Pharmaceutical Agents
  Author(s): Alexandros Repanas, Willem F. Wolkers, Oleksandr Gryshkov, Panagiotis Kalozoumis, Marc Mueller, Holger Zernetsch, Sotirios Korossis and Birgit GlasmacherAlexandros Repanas, Willem F. Wolkers, Oleksandr Gryshkov, Panagiotis Kalozoumis, Marc Mueller, Holger Zernetsch, Sotirios Korossis and Birgit Glasmacher
  
  Abstract Objective: Blend electrospinning has been acknowledged as a cost-effective technique for the production of fibrous scaffolds, suitable for various biomedical applications. Coaxial electrospinning is a method variant that results in core-shell structures with advantages, such as delayed diffusion and protection of sensitive biomolecules. The aim of this work was to evaluate how different process and solution parameters affect the structural, mechanical and physical properties of the fibers, created by polycaprolactone (PCL). In addition, acetylsalicylic acid (ASA) that was used as a model anti-inflammatory and anti-thrombotic agent, was loaded within the fiber meshes in order to compare release kinetics between fibers produced by conventional blend and coaxial electrospinning. Methods: Scanning electron microscopy (SEM) was used to investigate the structural and morphological .. View More»
  DOI: 10.4172/2161-1459.1000192

  Abstract PDF