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Oettinghaus Björn
Oettinghaus Björn
Institute of Pathology, University Hospital Basel,
Schönbeinstrasse 40, CH-4031 Basel
Switzerland
Publications
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Commentary
Lessons Learned from Transgenic Mouse Models for the Therapeutic Use of Drp1 Inhibitors
Author(s): Licci Maria and Oettinghaus BjörnLicci Maria and Oettinghaus Björn
Pharmacological inhibition of dynamin-related protein 1 (Drp1) the main mammalian promoter of mitochondrial fission - has emerged as a promising therapeutic target for the treatment of neuronal injuries. Genetic studies, however, have revealed that inhibiting Drp1 during development leads to defects especially in neuronal differentiation. Bypassing this neurodevelopmental impairment, a number of recent studies have genetically ablated Drp1 in different adult neuronal subpopulations. This has led to new insights into the importance of mitochondrial fission in differentiated neurons and has highlighted potentially severe side effects of this new therapeutic strategy. .. View More»
DOI: 10.4172/2168-9431.1000135