Biology and Medicine
Open Access
ISSN: 0974-8369
ISSN: 0974-8369
Nuri Gueven
Pharmacy, School of Medicine, Faculty of Health,
Hobart, TAS
Australia
Review Article
Optic Neurodegeneration: Time to Act
Author(s): Nuri GuevenNuri Gueven
Optic neuropathies are frequently associated with mitochondrial dysfunction and the associated vision loss has a severe impact on the patient’s quality of life. Our understanding of disease progression of one of the most frequent mitochondrial disorders, Leber’s hereditary optic neuropathy (LHON), together with results of recent clinical trials might provide us with new insights that are relevant not only to the progression of the disease but more importantly also for therapeutic intervention. One of the crucial hallmarks of LHON is the occasional recovery of vision in some patients. This rare and spontaneous process highlights that blindness in LHON patients is not irreversible per se and suggests that this process could potentially be induced by pharmacological intervention. Strikingly, spontaneous recovery of vision has been reported in some patients several years after.. Read More»
DOI:
10.4172/0974-8369.S1-001