Nthiga PM
Kenya
Research Article
Antipyretic, Antiinflammatory and Antinociceptive Activities of Aqueous Bark Extract of Acacia Nilotica (L.) Delile in Albino Mice
Author(s): Safari VZ, Kamau JK, Nthiga PM, Ngugi MP, Orinda G and Njagi EMSafari VZ, Kamau JK, Nthiga PM, Ngugi MP, Orinda G and Njagi EM
Acacia nilotica has been used to manage several diseases including pain, inflammation and fever. However, its efficacy has not been scientifically validated. The aim of this study therefore is to investigate the antinociceptive, antipyretic and anti-inflammatory activities of its aqueous extracts. The plant extract was collected from Loita division, Narok county in Kenya. A total of 96 albino mice with an average weight of 20 g was used for this study. Antinociceptive activity was determined by use of formalin−induced writhing test. A writhe was recorded by a stopwatch following the stretching of the abdomen and/or stretching of at least one hind limb. Anti-inflammatory activity was established by a formalin induced inflammation test. Hourly changes in paw sizes and reduction of edema around the paw was determined using a venier calipers. Antipyretic.. View More»
DOI:
10.35248/2684-1320.16.2.113