Journal of Pharmacovigilance

Nobuyuki Goto

Publications

• Research Article
  Physicochemical Properties of Causative Drugs Associated with Renal Nephrotoxicity
  Author(s): Reiko Yano, Fumiko Ohtsu and Nobuyuki GotoReiko Yano, Fumiko Ohtsu and Nobuyuki Goto
  
  Background: In this study, we examined the association between drug-induced renal nephrotoxicity and the physiochemical properties of the causative drugs we extracted from CARPIS in order to provide drug information about potential severe risks at the time of and after marketing approval. Methods: We designated the nephrotoxicity-associated drugs as the case drug group (126 drugs), and all other drugs were set as the control drug group (915 drugs). We compared the physicochemical properties of the group. We performed univariate logistic regression analysis on each investigation item, and then performed multivariate stepwise logistic regression analysis on the items which were p<0.2 using univariate logistic regression analysis. Results: Model 1, which uses a logP value, showed t.. View More»
  DOI: 10.4172/2329-6887.1000189

  Abstract PDF