Nobumasa Ohara
Japan
Research Article
Normal Response of Active GLP-1 Level like Substances to Test Meal in Non-Obese Type 2 Diabetic Japanese Patients with Complications and Receiving Treatments
Author(s): Kyuzi Kamoi, Nobumasa Ohara, Ikarashi Tomoo, You Shinozaki, Kazuo Furukawa and Hideo SasakiKyuzi Kamoi, Nobumasa Ohara, Ikarashi Tomoo, You Shinozaki, Kazuo Furukawa and Hideo Sasaki
Background: Study has shown no significant differences in basal and postprandial plasma active glucagon-like peptide-1 (p-active GLP-1) levels following test meal (TM) between complication- and treatment-naïve non-obese Japanese patients with type 2 diabetes (T2DM) and controls.
Methods: In non-obese Japanese patients with T2DM (n=23, group 1) and healthy individuals as control (n=13, group 2), blood levels of plasma glucose (PG), serum insulin (s-IRI), serum C-peptide (s-CPR) and p-active GLP-1 like substances (p-active GLP-1-S) were measured 0, 30, and 60 min after TM (520-560 kcal. 23% fat, 60% carbohydrate and 17% protein). HbA1c levels were also measured in the groups. Patients with mean of 9.2 years disease had various complications and treatment with diet, exercise and/or oral medical .. View More»
