Nils Wierup
Lund University Diabetes Centre Clinical Research Centre,
Jan Waldenströms gata 35, Malmö
Sweden
Research Article
Gastric Bypass Surgery Induces Changes in Gut Hormone-Producing Cell Populations in a Porcine Model
Author(s): Andreas Lindqvist, Mikael Ekelund, Stefan Pierzynowski, Leif Groop, Jan Hedenbro and Nils WierupAndreas Lindqvist, Mikael Ekelund, Stefan Pierzynowski, Leif Groop, Jan Hedenbro and Nils Wierup
Background: In most patients gastric bypass (GBP) causes remission of type 2 diabetes. It is established that plasma levels of gut hormones are affected by GBP, but it is not well understood how the enteroendocrine cells producing these gut hormones are affected by GBP. Objectives: We set out to investigate the effect of GBP on enteroendocrine cells in the stomach and intestine of pigs. Methods: Lean non-diabetic pigs were subjected to either GBP or sham-surgery and immunocytochemistry and morphometry for all major gut hormones in all parts of the GI-tract was performed. Sham-operated, pair-fed pigs were used as controls. Results: Postoperatively in the antrum, the density of gastrin-cells was lower (GBP 12.8±2.1 cells/μm2 versus sham 21.3±2.6 cells/μm2 ) while density of serotonin-cells was higher in GBP-pigs (GBP 21.6±2.3 cells/μm2 versus sham 10.6&plus.. View More»
