Journal of Blood Disorders & Transfusion

Nidhi L Chlebicka

Publications

• Research Article
  Invasive Mould Disease – Predictive Risk Factors in Acute Leukemia Patients Receiving Intensive Chemotherapy and its Impact on Survival
  Author(s): Gee Chuan Wong, Jenny GH Low, Nidhi L Chlebicka and Ban Hock TanGee Chuan Wong, Jenny GH Low, Nidhi L Chlebicka and Ban Hock Tan
  
  Background: Invasive mould disease (IMD) after chemotherapy in patients with acute leukemia has traditionally caused much morbidity and mortality. Methods: We conducted a retrospective, matched case-control study of IMD in patients with acute leukemia managed in our institution from January 2004 to March 2007 to determine the incidence and clinical outcomes of IMD, including its impact on 1-year survival. Results: During this period, 172 patients with acute leukemia underwent chemotherapy with curative intent. A probable or proven IMD developed in 19 patients (cases), giving an incidence of 11%. Aspergillus was the commonest mould. Cases were more likely than controls to have prolonged neutropenia, fever that did not respond to carbapenems, a bacteremia and a longer length of stay. Three-month survival was 93.3% among both cases and controls, but one-year survival was 46.7% among case.. View More»
  DOI: 10.4172/2155-9864.1000156

  Abstract PDF