Journal of Allergy & Therapy

Journal of Allergy & Therapy
Open Access

ISSN: 2155-6121

Nicola Scichilone

Nicola Scichilone
Sezione di Pneumologia,
“Villa Sofia-Cervello” Hospital, via Trabucco 180, 90146 Palermo

  • Review Article
    The Effect of Immunotherapy in Allergic Respiratory Diseases: Reappraisal of Current Knowledge
    Author(s): Rita Arrigo and Nicola ScichiloneRita Arrigo and Nicola Scichilone

    Allergic rhino-conjunctivitis and asthma are induced by sensitization to one or more allergens in susceptible individuals. Specific immunotherapy (SIT) is indicated in allergic diseases, because it modulates the immune response inducing peripheral T-cell tolerance and activation of regulatory T-cells. On this basis, SIT is considered the only therapeutic approach that can modify the natural history of the allergic diseases. The development of engineered-allergen has contributed to reduce the allergenicity thus preventing the risk of side effects. The monomeric allergoids, with structural conformation and molecular size that facilitate the mucosal absorption, carry a lower risk for side effects compared to the administration of native allergens, maintaining the immunological stimulation. The efficacy of SIT, administered percutaneously (SCIT) or sublingual (SLIT), has been largely demo.. Read More»
    DOI: 10.4172/2155-6121.1000171

    Abstract PDF

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