Journal of Allergy & Therapy
Open Access

Nicola Scichilone

Publications

• Review Article
  The Effect of Immunotherapy in Allergic Respiratory Diseases: Reappraisal of Current Knowledge
  Author(s): Rita Arrigo and Nicola ScichiloneRita Arrigo and Nicola Scichilone
  
  Allergic rhino-conjunctivitis and asthma are induced by sensitization to one or more allergens in susceptible individuals. Specific immunotherapy (SIT) is indicated in allergic diseases, because it modulates the immune response inducing peripheral T-cell tolerance and activation of regulatory T-cells. On this basis, SIT is considered the only therapeutic approach that can modify the natural history of the allergic diseases. The development of engineered-allergen has contributed to reduce the allergenicity thus preventing the risk of side effects. The monomeric allergoids, with structural conformation and molecular size that facilitate the mucosal absorption, carry a lower risk for side effects compared to the administration of native allergens, maintaining the immunological stimulation. The efficacy of SIT, administered percutaneously (SCIT) or sublingual (SLIT), has been largely demo.. Read More»
  DOI: 10.4172/2155-6121.1000171

  Abstract PDF

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