Biology and Medicine

Ngatidjan

Publications

• Research Article
  The Effect of Telmisartan on Bone Morphogenetic Protein-7 (BMP-7) Expression in the Kidney of 8% Sodium Chloride-Treated Rats
  Author(s): Khairil Pahmi, Ricky M Ramadhian and NgatidjanKhairil Pahmi, Ricky M Ramadhian and Ngatidjan
  
  Excessive salt consumption is one of the hypertension factor leads to kidney disease, while telmisartan is one of antihypertensive drugs used in the therapy. Telmisartan not only blocks angiotensin receptor leads to the decrease of blood pressure, but it also activates peroxisome proliferator activated receptor gamma (PPAR-γ), inhibits transforming growth expression factor of beta-1 (TGFβ-1) and increases bone morphogenetic protein-7 (BMP-7). Whether telmisartan increases BMP-7 expression of excessive NaCl–induced Wistar rats are studied in this experiment. Twenty five male Wistars 2.5-3 months of age and 100-150 g BW rats were used in this research. They were grouped into 5, each consists of 5 rats. Group I (G I) as first negative control did not receive NaCl and telmisartan. G II as second negative control received NaCl but not telmisartan. G III, IV and V received NaC.. View More»
  DOI: 10.4172/0974-8369.1000437

  Abstract PDF