Biochemistry & Analytical Biochemistry

Biochemistry & Analytical Biochemistry
Open Access

ISSN: 2161-1009

Nese Atabey

Nese Atabey


  • Review Article
    Platelets, Microenvironment and Hepatocellular Carcinoma
    Author(s): Yeliz Yilmaz, Esra Erdal, Nese Atabey and Brian I. CarrYeliz Yilmaz, Esra Erdal, Nese Atabey and Brian I. Carr

    Hepatocellular carcinoma (HCC) is the commonest type of liver cancer and has a high mortality rate. Currently treatment options are limited and new therapies are urgently needed. Platelets are enucleated small cells, derived from mature megakaryocytes and besides their role in thrombosis; they actively take part in carcinogenesis and metastasis. Platelet number in the blood is associated with disease progression, overall survival and HCC subgrouping. Both thrombocytosis and thrombocytopenia are associated with HCC phenotype and size, related with other factors like cirrhosis background. Platelet counts and also platelet-to-lymphocyte ratio (PLR) and neutrophil-tolymphocyte ratio (NLR) are considered in decision making in management. Since platelets also take up nucleotides and cytokines from tumor cells, isolating and studying platelets might provide valuable information for understan.. Read More»
    DOI: 10.4172/2161-1009.1000281

    Abstract PDF

Relevant Topics