Nagata T

Nagata T
Graduate School of Medicine and Pharmaceutical Sciences for Research,
Sugitani 2630, Toyama
Japan

Publications
  • Research Article
    Anti-cancer Effect of Saxifraga stolonifera Meerb
    Author(s): Nagata T, Win N, Xiao Long L, Miwa T, Okumura T, Fushimi H, Morita H and Shimada YNagata T, Win N, Xiao Long L, Miwa T, Okumura T, Fushimi H, Morita H and Shimada Y

    Background: Saxifraga stolonifera Meerb (SSM) or Yukinoshita in Japanese has been used as a medicinal plant in China and Japan since ancient times. We conducted this research to evaluate the antitumor effects of SSM and explored antitumor factors. Methods: An extract of SSM was added to cultured cells of various cancers to assess its anti-proliferative effect. Next, a peritoneal dissemination model was created by intraperitoneally injecting gastric cancer cells (NKN45) to each nude mouse. Then, the extract of SSM was orally administered to the mice to evaluate its antineoplastic effect in vivo. In addition, in order to identify antitumor phytoconstituents, isolation and fraction of active CHCl3 extract of SSM was carried out by chromatographic methods. Results: The extract of SSM showed potent antitumor effects in cultured cells of esophageal, gastric, and breast cancers in a concentrati.. View More»
    DOI: 10.4172/2161-1459.1000211

    Abstract PDF