Hereditary Genetics: Current Research

Hereditary Genetics: Current Research
Open Access

ISSN: 2161-1041


Nadja Bogdanova

  • Review Article
    Hereditary Thrombophilic Risk Factors for Recurrent Pregnancy Loss
    Author(s): Arseni Markoff, Nadja Bogdanova and Meyer Michel SamamaArseni Markoff, Nadja Bogdanova and Meyer Michel Samama

    This review summarizes current knowledge about the role of hereditary hypercoagulation factors predisposing to thrombophilia-associated recurrent fetal loss. Thrombophilias are a major cause of adverse pregnancy outcome, playing a role in the etiology of up to 40% of cases worldwide. Hereditary thrombophilic predispositions to recurrent pregnancy wastage include genetic lesions in blood coagulation factors II and V as well as natural anticoagulants antithrombin, protein C and protein S. Furthermore, these gene defects confer higher thrombophilia risk in combination. They, as well as the newly described annexin A5 gene M2 promoter allele are associated with repeated fetal loss. The review gives a concise description of the molecular defects arising from the genetic changes, of the role these factors play in the timing and definition of fetal loss, and risk estimates from available stud.. Read More»
    DOI: 10.4172/2161-1041.S1-001

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