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Muhammad Tahir M Bhinder
Muhammad Tahir M Bhinder
Tanzania
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Research Article
Pharmacogenetic Testing for Methotrexate Treatment in Leukemia Patients
Author(s): Muhammad Tahir M Bhinder, Amin Saleh Halum, Suhaib M Muflih and Mohammad ShawaqfehMuhammad Tahir M Bhinder, Amin Saleh Halum, Suhaib M Muflih and Mohammad Shawaqfeh
Background: Pharmacogenetic testing can be used as a means to individualize a patient’s medical regimen in order to prevent future adverse drug events. Pharmacogenomics looks at individual genes and can predetermine a patient’s susceptibility to certain side effects of medications, as well as how efficacious a medication will be for that patient. Methotrexate has been shown to exhibit different responses based on the genetic expressions and variations of the genes SLC19A, SHMT, ABCB1, ATIC and MTHFR. Objective: To determine the clinical relevance of pharamcogenetic testing for leukaemia patients treated with Methotrexate. Method: A systematic review was conducted from September 2013-August 2015, primarily using the EMBASE and PubMed databases, identifying Cochrane reviews, controlled clinical trials, ra.. View More»
DOI: 10.4172/2167-7956.1000134