Journal of Diabetes & Metabolism

Journal of Diabetes & Metabolism
Open Access

ISSN: 2155-6156


Monireh Dashty

Monireh Dashty
University Medical Center Groningen,
Antonius Deusinglaan 1, 9713 AV, Groningen

  • Review Article
    Hedgehog Signaling Pathway is Linked with Age-Related Diseases
    Author(s): Monireh DashtyMonireh Dashty

    Disorders related to chronic inflammation and ageing such as metabolic syndrome, atherosclerosis, osteoporosis and cancers appear to have different pathogenesis. However, by studying the pathways related to the stem cell (SC) signaling network, like Hedgehog signaling and in particular its influence on the adipogenesis - osteogenesis interaction, we could find a close link between the pathogenesis of these disorders. Hedgehog signaling is an active pathway during embryogenesis that seems to be silent in adults. However, it strongly affects the maintenance of adult tissue homeostasis and the highly proliferative and differentiated cells (e.g., SCs, adipocytes and osteocytes). Malfunction of these cells is considered as the basic etiology of a group of age-related diseases such as atherosclerosis, osteoporosis and cance.. Read More»
    DOI: 10.4172/2155-6156.1000350

    Abstract PDF

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