Mohammad Shabani
West Indies
Research Article
Neuroprotective Effect of Cerebrolysin on Diabetic Neuropathy: A Study on Male Rats
Author(s): Nasser Zangiabadi, Hossein Mohtashami, Mohammad Shabani and Mandana JafariNasser Zangiabadi, Hossein Mohtashami, Mohammad Shabani and Mandana Jafari
Objective: Diabetes mellitus with 10% prevalence in human population leads to disorders of peripheral nervous system in many affected patients. It causes various polyneuropathies in which nerve conductionvelocity decreases. The aim of this study was to investigate the effect of cerebrolysinon the treatment of neural injuries resulted from hyperglycemia.
Method: Diabetes was induced in male rats weighing 250 ± 25 gr by intraperitoneal injection of 65 mg/kg streptozocin (STZ). Six weeks after STZ injection and appearance of neuropathy in diabetic rats, animals were divided into four groups: experimental, vehicle, diabetic and control. The experimental and vehicle groups received respectively single dose of 5 mg/kg day-1 cerebrolysinand saline intraperitoneally for two weeks. At the end, in order to find the efficacy of cerebrolysin, all.. View More»
