Mohamed Mohamed Ismail
Faculty of Medicine, Cairo University Kasr Alainy,
Cairo
Egypt
Research Article
Urinary Smad1 as a New Biomarker for Diabetic Nephropathy in Patients with Type 1 Diabetes Mellitus
Author(s): Mohamed Mohamed Ismail and Sally kamal IbrahimMohamed Mohamed Ismail and Sally kamal Ibrahim
Introduction: Type 1 diabetes mellitus is an autoimmune disease affecting children worldwide with many consequences disturbing their quality of life. Diabetic nephropathy is among the most important complications of T1DM. The reliability of albuminuria as a predictor and prognosticator for renal injury has been frequently questioned. Many markers were investigated to replace urinary albumin. The current study aimed to assess the potential value of urinary Smad1 as a new biomarker for the early diagnosis and assessment of severity of diabetic nephropathy in children with.
Material and method: A case control cross sectional study with 53 patients with type 1 diabetes mellitus. 30 patients with diabetic nephropathy including 19 patients with microalbuminuria (urinary albumin creatinine ratio: 30-300 mg/gm) and 11 patients with macroalbuminuria .. View More»
