Journal of Clinical & Experimental Pharmacology

Mónica Sparo

Publications

• Research Article
  Bacterial Antagonist Mediated Protein Molecules
  Author(s): Lucía Urbizu, Mónica Sparo and Sergio Sánchez BruniLucía Urbizu, Mónica Sparo and Sergio Sánchez Bruni
  
  Bacterial antagonism mediated by ribosomally synthesised peptides has gained considerable attention in recent years because of its potential applications in the control of undesirable microbiota. These peptides, generally referred to as bacteriocins, are defined as a heterogeneous group of ribosomally synthesised, proteinaceous substances (with or without further modifications) extracellularly secreted by many Gram-positive and some Gram-negative bacteria. Their mode of activity is primarily bactericidal and directed against closely related strains and species. These peptides are nearly all cationic and very often amphyphilic, which is reflected in the fact that many of these peptides kill their target cells by accumulation in the membrane causing increasing permeability and loss of barrier functions . Bacteriocins have been explored primarily as natural food preservatives, but there .. View More»
  DOI: 10.4172/2161-1459.1000123

  Abstract PDF