Journal of Data Mining in Genomics & Proteomics

Mishra S

Publications

• Research Article
  Computational Approach to Identify the Major Histocompatibility Complex Binding Antigenic Peptides from ‘Ascariasis’
  Author(s): Mishra S and Gomase VSMishra S and Gomase VS
  
  The Ascaris lumbricoides cause ‘ascariasis’ in human and its elimination is the major public concern. In this current investigation, we predicted the MHC (Major Histocompatibility Complex) class I & II binding peptides with computational approach like PSSM (Position Specific Scoring Matrices) and SVM (Support Vector Machine) algorithms. We predict the peptide binders of Cytochrome b (mitochondrion) protein from Ascaris lumbricoide sequence to MHC-I molecules are as 11mer_H2_Db, 10mer_H2_Db, 9mer_H2_Db, 8mer_H2_Db. Also study integrates prediction of peptide MHC class I binding; proteasomal C terminal cleavage and TAP transport efficiency by using sequence and properties of the amino acids. We also found the binding of peptides to different alleles by using Position Specific Scoring Matrix. Cytochrome B from Ascaris lumbricoides (365 residues long) with 357 nonamers hav.. View More»
  DOI: 10.4172/2153-0602.1000198

  Abstract PDF