Min-Hua Chen
Chung Yuan Christian University200,
Chung Pei Road, Taoyuan City 32023
People's Republic of China
Hypothesis
An Idea of Using Microneedles for the Targeted Drug Delivery to Overcome the Blood Brain Barrier for the Treatment of Brain Diseases
Author(s): Lokesh Agrawal, Sunil Kumar Vimal, Min-Hua Chen and Takashi ShigaLokesh Agrawal, Sunil Kumar Vimal, Min-Hua Chen and Takashi Shiga
Drug delivery and vaccination have become the most challenging issues recently in the patients who suffer from severe form of central nervous system diseases along with mild or severe bleeding disorders. In conventional drug delivery system, drug delivery through blood brain barrier remains a big challenge. Additionally, administration of such drugs by syringe injection has many limitations such as pain at the site of injection, infection, hemorrhage, anxiety as well as high cost and incompetency towards patients. Therefore, the proposed hypothesis focusses on the fabrication and development of solid, water soluble and biodegradable microneedles which aims to overcome the disadvantages of conventional drug delivery system. These microneedles loaded with calcium phosphate nanoparticles easily combine with mononuclear phagocytic cells (macrophages/monocytes) which serve as nanocarriers .. View More»
DOI:
10.4172/2329-6887.1000270