Miles F. Lankford

Publications
  • Research Article
    Increasing Oxygen in Hypoxic Tumors
    Author(s): John L. Gainer and Miles F. LankfordJohn L. Gainer and Miles F. Lankford

    Background: Tumors are frequently hypoxic, affecting both chemotherapy and radiotherapy. Trans sodium crocetinate (TSC), a novel pharmaceutical agent, causes increases in oxygen levels of hypoxic tissues. It has also been shown, in animal models of cancer, that radiotherapy is more effective when used in conjunction with TSC. An increase in tumor oxygen should also affect the HIF-1? pathway. Thus, an in vitro study of that pathway in human glioblastoma cells was performed. Methods: This study involved the use of quantitative real time polymerase chain reaction technology and human glioblastoma multiforme cells. The cells were cultured under both hypoxic and normoxic conditions. Results: The inclusion of TSC in the media of the cells resulted in some genes in the HIF-1? pathway being either up- or down-regulated in a statistically-significant manner. These changes were opposite to those w.. View More»
    DOI: 10.4172/2161-1459.1000103

    Abstract PDF