Journal of Clinical & Experimental Pharmacology

Mebrahtu Eyasu

Publications

• Research Article
  Evaluation of Diuretic Activity of Hydro-Ethanolic Extract of Moringa Stenopetala Leaves in Swiss Albino Mice
  Author(s): Bekesho Geleta, Mebrahtu Eyasu, Netsanet Fekadu, Asfaw Debella and Feyissa ChallaBekesho Geleta, Mebrahtu Eyasu, Netsanet Fekadu, Asfaw Debella and Feyissa Challa
  
  Abstract Context: Moringa stenopetala (Baker f) Cufodontis is an evergreen tree of approximately 5 to 10 m height and widely distributed in the Southern parts of Ethiopia with numerous nutritional and medicinal purposes. Objective: The aim of the study was to evaluate the effect of hydro-ethanolic extract of M. stenopetala leaves using in-vivo mice model of diuresis. Methods: Furosemide (10 mg/kg), normal saline (1 ml/100 g), and extract doses (150, 250, 350, 500 and 1000 mg/kg) of body weight were used as standard, control and test substance respectively. All substances were administered orally. The urine output and electrolyte concentration of Na+, K+ and Cl- were determined. Results: At all doses the experimental group had a significant urine output at 0.5 hour and 1 hour (P < 0.001) compared to standard and control. After 2.5 hours, at 500 mg/kg the extract showed an increased .. View More»
  DOI: 10.4172/2161-1459.1000190

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