Immunologic Pattern of Hepatitis B Infection among Exposed and Non-Exposed Babies in A PMTCT Program in Low Resource Setting: Does Every Exposed Newborn Require 200IU of Hepatitis B Immunoglobulin?
Author(s): Onakewhor JUE, Charurat M, Matthew O, Esosa Osagie, Asemota MO and Omoigberale AOnakewhor JUE, Charurat M, Matthew O, Esosa Osagie, Asemota MO and Omoigberale A
Background: Hepatitis B (HBV) is a vaccine-preventable infection. Vaccination programs instituted for virtual elimination of vertical and horizontal transmission are rarely evaluated. The prohibitive cost of HBV immunoprophylaxis (HBIG) engenders restrictive access in low-resource settings. Objective: Comparison of the immunologic pattern of HBV seromarkers and mother-to-child transmission (MTCT) rates among exposed and non-exposed babies who received either standard 200 iu or 100 iu HBIG in resource low settings. Method: This prospective pilot observational study involved a cohort of HBV-infected pregnant women and exposed babies and HBV-uninfected women-baby pairs as control at the Department of Obstetrics and Gynecology, UBTH, Nigeria. HBV seromarkers were detected using rapid, direct, third generation immunochromatographic test for qualitative monoclonal and polyclonal anti-HBsAg .. Read More»