Journal of Nutritional Disorders & Therapy

Masaki Fujita

Publications

• Research Article
  Attenuation of Pulmonary Mycobacterium Avium Disease by Active Hexose Correlated Compound (AHCC) in Mice
  Author(s): Masaki Fujita, Takemasa Matsumoto, Ryosuke Hirano, Kazunari Ishii, Kenji Hiromatsu, Junji Uchino and Kentaro WatanabeMasaki Fujita, Takemasa Matsumoto, Ryosuke Hirano, Kazunari Ishii, Kenji Hiromatsu, Junji Uchino and Kentaro Watanabe
  
  Introduction: Pulmonary Mycobacterium avium disease is a chronic and progressive disease that is known to be difficult to treat. Active hexose correlated compound (AHCC) is an extract obtained by culturing mycelia of Basidiomycota. AHCC is reported to attenuate several experimental animal infection models. We hypothesized that AHCC could attenuate pulmonary M. avium disease in mice. Methods: Mycobacterium avium (108 cfu/head) was administered intratracheally into mice (C57/BL6). Infected mice were supplied with 1,000 mg/kg/day of AHCC by oral administration until euthanasia. The mice were sacrificed at seven days later or 21 days later after M. avium infection. The lung homogenates were cultured on Middlebrook 7H10 agar plates for bacterial colony counts. Additionally, the number of inflammatory cells in the .. View More»
  DOI: 10.4172/2161-0509.1000174

  Abstract PDF