Bioenergetics: Open Access

Bioenergetics: Open Access
Open Access

ISSN: 2167-7662

Martha Calahorra

Martha Calahorra
Institute of Cellular Physiology,

  • Research Article
    Effects of Acridine Derivatives on Ca2+ Uptake by Candida albicans
    Author(s): Martha Calahorra, Norma Silvia Sánchez and Antonio PeñaMartha Calahorra, Norma Silvia Snchez and Antonio Pea

    The effects of several acridine derivatives, and chloroquine, which has a similar lateral chain to quinacrine, but with a quinoline nucleus, were studied on a strain of Candida albicans. Parameters estimated were: a) dichloromethane/water partition coefficients; b) uptake by cells; c) effects on respiration, d) effects on the acidification of the medium; e) efflux of K+; f) uptake of 86Rb+ and 45Ca2+, and d) effects on growth of cells. Results obtained in general: a) most of them showed a low hydrophobicity; b) most of them were significantly taken up by cells; c) acridine orange, acridine yellow, quinacrine and nonyl acridine orange inhibited respiration; d) acridine orange, quinacrine and nonyl acridine orange inhibited acidification of the medium. The most significant finding was that acridine orange, quinacrine and nonyl acridine orange at 60 μM or 120 μM, and.. Read More»
    DOI: 10.4172/2167-7662.1000152

    Abstract PDF

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