Journal of Pharmacovigilance

Maria Grazia Perrone

Publications

• Research Article
  A Combined HPLC and LC-MS Approach for Evaluating Drug Stability in Elastomeric Devices: A Challenge for the Sustainability in Pharmacoeconomics
  Author(s): Patrizia Nardulli, Elena Capparelli, Maria Grazia Perrone, Simona Ferraiuolo, Maria Rita Laforgia, Claudia Crapolicchio and Nicola Antonio ColabufoPatrizia Nardulli, Elena Capparelli, Maria Grazia Perrone, Simona Ferraiuolo, Maria Rita Laforgia, Claudia Crapolicchio and Nicola Antonio Colabufo
  
  Objectives A longer postoperative care, needed for patients admitted to the hospital, is expensive and associated with increased morbidity and mortality, when compared with the outpatient setting. Outpatient therapy with continuous infusion of drugs with elastomeric pumps represents an effective method to address this problem. The aim of this work is to analyse the benefits in using elastomeric devices and to test their their behaviour towards drugs to changes during storage that could influence quality, safety and efficacy of the therapy. Methods Several drugs belonging to different therapeutic classes, including anticancer, analgesic opioids, local anesthetics and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) h.. View More»
  DOI: 10.4172/2329-6887.1000157

  Abstract PDF