Maria Alice Rostom de Mello
Brazil
Research Article
Effects of Moderate Intensity Physical Training in Neonatal Alloxan- Administered Rats
Author(s): Carla Ribeiro, Clécia Soares de Alencar Mota, Fabrício Azevedo Voltarelli, Michel Barbosa de Araújo, José Diego Botezelli, Camila Aparecida Machado de Oliveira and Maria Alice Rostom de MelloCarla Ribeiro, Clécia Soares de Alencar Mota, Fabrício Azevedo Voltarelli, Michel Barbosa de Araújo, José Diego Botezelli, Camila Aparecida Machado de Oliveira and Maria Alice Rostom de Mello
Newborn rats (6 days old) received alloxan intraperitoneally (A= 250 mg/kg b.w). Rats injected with vehicle (citrate buffer) were used as controls (C). After weaning, half of the animals were submitted to 1 hour/day, 5 days/week swimming and with supporting overload of 5% b.w. At 28 days, no signi fi cant differences were found among the groups in fasting glycemia and insulinemia. At 60 days, the fasting glycemia (30 min after oral glucose administration) was higher in alloxan than in controls groups and lower in the alloxan group submitted to training than in the correspondent sedentary group. The glucose tolerance of the alloxan rats was reduced in comparison to controls, both at 28 and 60 days, since the area under the blood glucose curve during the OGTT was higher in the alloxan than in the control. No difference was found among the g.. View More»
