Journal of Stem Cell Research & Therapy

Marcellino Monda

Publications

• Research Article
  Sera of Overweight Patients Alter Adipogenesis and Osteogenesis of Bone Marrow Mesenchymal Stromal Cells, a Phenomenon that also Persists in Weight Loss Individuals
  Author(s): Angela Ferone, Giovanni Messina, Nicola Alessio, Stefania Capasso, Marilena Cipollaro, Marcellino Monda, Gianfranco Peluso, Umberto Galderisi and Giovanni Di BernardoAngela Ferone, Giovanni Messina, Nicola Alessio, Stefania Capasso, Marilena Cipollaro, Marcellino Monda, Gianfranco Peluso, Umberto Galderisi and Giovanni Di Bernardo
  
  Background: Overweight and obesity represents a complex interaction of genetics, diet, metabolism, and physical activity. Abnormal or excessive body fat accumulation increases the risk of pathologies, such as heart disease, diabetes, and high blood pressure. Methods and results: In a previous paper, we investigated the influence of overweight individuals’ sera on in vitro biology of mesenchymal stromal cells, which contain a subpopulation of multipotent stem cells. This report extended the study by evaluating effects of sera collected from weight loss patients on stromal cultures. Results showed that an increase in fat mass induces physiological changes that negatively impact on stromal stem cell adipogenesis and osteogenesis with a bias toward adipocyte differentiation. This phenomenon occur.. View More»
  DOI: 10.4172/2157-7633.1000347

  Abstract PDF