Hereditary Genetics: Current Research

Hereditary Genetics: Current Research
Open Access

ISSN: 2161-1041


Manuel S. Valenzuela

Manuel S. Valenzuela
School of Medicine, Meharry Medical College, 1005 D.B. Todd Jr. Boulevard,
Nashville, TN 37208

  • Review Article
    Initiation of DNA Replication in the Human Genome
    Author(s): Manuel S. ValenzuelaManuel S. Valenzuela

    Replication of the human genome relies on the presence of thousands of origins distributed along each of the chromosomes. The activation of these origins occurs in a highly regulated manner to ensure that chromosomes are faithfully duplicated only once during each cell cycle. Failure in this regulation can lead to abnormal cell proliferation, or/ and genomic instability, the hallmarks of cancer cells. The mechanisms determining how, when, and where origins are activated remains still a mystery. However recent technological advances have facilitated the study of DNA replication in a genome-wide scale, and have provided a wealth of information on several features of this process. Here we present an overview of the current progress on our understanding of the initiation step of DNA replication in human cells, and its relationship to abnormal cell.. Read More»
    DOI: 10.4172/2161-1041.S1-003

    Abstract PDF

Relevant Topics