Manikandan E
India
Research Article
Acute and Repeated Oral Toxicity of Antidiabetic Polyherbal Formulation Flax Seed, Fenugreek and Jamun Seeds in Wistar Albino Rat
Author(s): Latha S, VijayaKumar R, Senthil Kumar BR, Bupesh G, Shiva VijayaKumar T, Manikandan E, Maaza M, Sri kumar R and Deepika VLatha S, VijayaKumar R, Senthil Kumar BR, Bupesh G, Shiva VijayaKumar T, Manikandan E, Maaza M, Sri kumar R and Deepika V
Polyherbal formulations treating for various diseases bring attention to the human society. The toxicity and its safe dosage should be studied for dose optimization and formulation. The aim of this study was to evaluate acute and repeated oral toxic effect of the hydroalcoholic extract of polyherbal formulation such as flax seed, fenugreek and jamun seed (FFJ) on wistar albino rats. Acute toxicity was tested by single oral stepwise administration of the drug at the dose of 300 mg, 2000 mg and 5000 mg/kg bw. The toxicity and mortality were observed for every 30 minutes for first 24 hours and then day by day for 14 days. At the 29th day, the blood was collected by Sino orbital puncture for analysis of hematological and biochemical parameters. Then the animals were killed by cervical decapitation and organs were separated and weighed. The results showed that no toxic sym.. View More»
