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Makoto Onizuka
Makoto Onizuka
Tokai University School of Medicine,
143 Shimokasuya, Isehara, Kanagawa, 259-1143
Japan
Publications
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Research Article
Noninfectious Pulmonary Complications after Stem Cell Transplantation and Induction of an Innate Immune Response
Author(s): Makoto Onizuka, Koich Miyamura, Mitsuki Miyamoto and Kiyoshi AndoMakoto Onizuka, Koich Miyamura, Mitsuki Miyamoto and Kiyoshi Ando
Introduction: Non-infectious pulmonary dysfunction (NIPC) represents a common and often fatal complication of hematopoietic stem cell transplantation (HSCT). Recently, bactericidal/permeability-increasing (BPI) haplotypes were associated with an increased risk of developing airflow decline after HSCT. Objective: In order to clarify whether BPI is involved in the pathogenesis of HSCT-related pulmonary complications, we performed a genetic association study. Methods: In this study, we therefore investigated the relationship between BPI and pulmonary dysfunction within an ethnic group by analyzing the incidence of NIPC based on genotype and the allelic frequency of BPI polymorphisms in 121 Japanese patients who underwent HSCT from HLA-identical sibling donors. We examined BPI-associated single nucleotide polymorphisms (SN.. View More»