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Linda Hazlett D
Linda Hazlett D
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit Michigan,
United States
Publications
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Research Article
Pseudomonas Keratitis, a Review of Where Wehave Been and What Lies Ahead
Author(s): Alicia Eby M and Linda Hazlett DAlicia Eby M and Linda Hazlett D
Microbial keratitis can result in significant vision loss secondary to corneal scarring or surface irregularity. If untreated, corneal perforation and endophthalmitis can occur, resulting in loss of the eye. Damage to the cornea can occur in as little as 24 hrs and the most aggressive infections are often caused by P. aeruginosa which is a highly virulent opportunistic pathogen. This bacterium is highly effective at evading the immune response and blunting it via several mechanisms. Normally the innate immune system provides defense with neutrophils which are recruited within as little as 6-12 hrs of infection travelling from limbal vessels via the tear film to the site of the infection. These cells play a critical role in limiting bacterial proliferation as well as protecting host tissue from destruction, but if they persist locally they are detrimental, inducing additional tissue da.. View More»
DOI: 10.4172/1948-5948.1000254