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Lígia Maria Suppo Souza Rugolo
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Research Article
Selenium and Vitamin A and E in the Nutrition of Very Low-Birth Weight Preterm Infants
Author(s): Cleide Enoir Petean Trindade and Lígia Maria Suppo Souza RugoloCleide Enoir Petean Trindade and Lígia Maria Suppo Souza Rugolo
Deficient antioxidant defenses in preterm infants have been implicated in diseases such as bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, periventricular leukomalacia, and intraventricular hemorrhage. The antioxidant properties of selenium, vitamin A, and vitamin E make these elements important in the nutrition of Very Low-Birth Weight (VLBW) infants. Selenium is a component of glutathione peroxidase, an enzyme that prevents the production of free radicals. The decrease in plasma selenium in VLBW infants in the first month after birth makes evident that preterm infants have low selenium store and require supplementation by parenteral and enteral nutrition. A meta-analysis, with only three trials, showed that selenium supplementation did not affect mortality, and the incidence of neonatal chronic lung disease or retinopathy of prematurity, but .. View More»