Cardiovascular Pharmacology: Open Access
Open Access
ISSN: 2329-6607
ISSN: 2329-6607
Leydimar Anmad Shihadeh
Spain
Review Article
Horizons in Novel Oral Anticoagulation Therapy in Concomitant Acute Coronary Syndromes and Atrial Fibrillation
Author(s): Leydimar Anmad Shihadeh, Diego Fernández-Rodríguez, Javier Lorenzo-González and Julio Hernández-AfonsoLeydimar Anmad Shihadeh, Diego Fernández-Rodríguez, Javier Lorenzo-González and Julio Hernández-Afonso
Thrombus formation and coronary artery occlusion, in acute coronary syndromes, occur as a result of an atherosclerotic plaque rupture/erosion and the subsequent activation of platelets and coagulation factors. Also, cardioembolic events, in atrial fibrillation, are related to the thrombus formation and the systemic arterial embolization secondary to the blood stasis in left atrium.
Antiplatelet treatments in acute coronary syndromes and long-term oral anticoagulation in atrial fibrillation have improved prognosis by reducing ischemic events but both treatments are associated with an increase in the risk of bleeding. Furthermore, thrombin and activated factor X are the key elements in the coagulation cascade and novel oral anticoagulants act by inhibiting these coagulation factors, generating a double effect: the reduction of ischemic events and the increment in hemorrhagic eve.. Read More»
DOI:
10.4172/2329-6607.1000155