Leila Sadeghi
Switzerland
Research Article
Know-how and Know-why Nutrients may be Less Bioaccessible and Less Bioavailable due to Proton Pump Inhibitor - Food Interactions and Incompatibilities Involving Metal-Aquo Complexes
Author(s): Helena Jenzer, Irene Marty, Sandra Büsser, Marta Silva, Franziska Scheidegger-Balmer, Linda Jennifer Ruch, Sofia Martins, Noëmi Dajanah Maurer-Brunner, Francesca Rotunno and Leila SadeghiHelena Jenzer, Irene Marty, Sandra Büsser, Marta Silva, Franziska Scheidegger-Balmer, Linda Jennifer Ruch, Sofia Martins, Noëmi Dajanah Maurer-Brunner, Francesca Rotunno and Leila Sadeghi
Background: Proton pump inhibitors change gastric pH from around 2.0 to 2.5 to more than 4.0 for up to 16 hours per day and suppress gastric function widely. Risk factors assigned to long-term inhibition of gastric acidity arise from cleavage-resistance of peptides and glycosides, mucosal degeneration and leak, loss of bactericidal action, and modification of absorption kinetics of medicines and nutrients. This article aims to contribute to wisely use of proton pump inhibitors and to recommend nutritional options.
Methods: A systematic online literature research was performed on usual platforms. Recommendations rely on a multidisciplinary focus group assessment. Explanations arising from the retrieved references were tested for consistency by titration of iron solution from acidic to basic pH while observing precipitation... View More»
DOI:
10.4172/2161-0509.1000191