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Laura Cooling
Laura Cooling
Transfusion Medicine University of Michigan Hospitals 2F225 UH Blood Bank,
Box 0054 1500 East Medical Center Drive Ann Arbor, MI 48109-0054
Tanzania
Publications
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Research Article
Inferior Vena Cava Filters as a Potential Non-immune Cause of Low Serum Haptoglobin
Author(s): Laura Cooling, Donald Giacherio and Matthew ElkinsLaura Cooling, Donald Giacherio and Matthew Elkins
Objective: Serum haptoglobin level is commonly used as a marker of hemolysis. We hypothesized that inferior vena cava (IVC) filters may be a potential non-immune etiology for subclinical hemolysis and low haptoglobin in some patients, after encountering a patient with an IVC filter, mild macrocytic anemia and unexplained severe haptoglobinemia. IVC filters can be associated with pressure gradients and turbulent blood flow in the presence of trapped clots and thrombus formation. Methods: Prospective study in patients undergoing IVC filter placement at our institution over a 3-month period in 2008. All patients had a haptoglobin level prior to filter placement, and then daily for a period of 3-14 days. The absolute and relative change in haptoglobin compared to pre-procedure levels was determined. Results were evaluated by t-test (paired, 2-tail.. View More»
DOI: 10.4172/2155-9864.1000382