Kouichi Tanabe
Japan
Research Article
Exploring Risk Factors that Contribute to the Onset of Ritodrine-Associated Serious Adverse Drug Reactions
Author(s): Chiyo Mori, Reiko Yano, Takamasa Sakai, Jinsaku Sakakibara, Kouichi Tanabe, Nobuyuki Goto and Fumiko OhtsuChiyo Mori, Reiko Yano, Takamasa Sakai, Jinsaku Sakakibara, Kouichi Tanabe, Nobuyuki Goto and Fumiko Ohtsu
Background: Ritodrine is a drug used for threatened premature labor. The severe adverse drug reactions associated with ritodrine are known to be pneumonedema, leukopenia, and rhabdomyolysis, but there have been few investigations on the risk factors. We performed a case-control study and selected case reports as a case group and healthy pregnant women in clinical practice as a control group. Methods: We extracted the onsets of pneumonedema, leukopenia, and rhabdomyolysis associated with ritodrine from case reports in Japan as a case group. We selected healthy pregnant women with ritodrine administration in clinical practice as a control group. We investigated their age, medical history; Pregnancy Induced Hypertension (PIH), multiple pregnancies, concomitant drugs administered, and maximum rate of ritodrine infusion, and examined the association with those factors with the onset of adv.. View More»
DOI:
10.4172/2329-6887.1000224